My first best friend died from muscular dystrophy. The first patient I ever saw in a hospital as a mere orderly was suffering from pain, agony, and distention. He was a fairly young man who had colon cancer.
I have been frequently horrified at the level of suffering that people have to endure. It is incredible the horror that can be inflicted upon human beings.
Several times I've started a list about the 10 worst diseases. The hell on earth that people endure. It is going to feel running thread with me. I will have to update the list periodically.